Preclinical

2020 : Reproductive Health
Aphrodisiac composition and management of male sexual dysfunction.

Majeed M, Nagabhushanam K, Bani S and Pandey A.

US 10,864,242

Overview

The patent discloses a composition for therapeutic management of male sexual dysfunction and related disorders. The composition WithanAlpha™ comprises of Withania somnifera extract (Shagandha®), Mucuna pruriens extract (MucunAmine™), Coleus forskohlii extract (ForsLean®), Kaempferia parviflora extract (Thealis™) and Piper nigrum extract (BioPerine®), for use as an aphrodisiac.

Study Design

The experiment was conducted in male Wistar rats and observed for the reproductive performance studies. Both behavioral and biochemical assessments were carried out.

Dose

The rats were given three different doses of the formulation, 50, 100 and 200 mg/kg body weight.

Results
  • Non-estrous female rats were paired with males treated with a single dose of the formulation. There was an increase in the number of mounts significantly, indicating it is a very effective aphrodisiac
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  • Testosterone levels increased throughout the use of formulation, proving to be a safe and long-term solution for improved testosterone
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  • Androstenedione level increased in serum of treated animals after 1 hour of administration of the formulation
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  • An increase in cGMP and cGMP – PK1 concentration in serum of treated animals after 1 hr of administration of the formulation was observed. cGMP causes smooth muscles in the arteries to relax, increasing blood flow, thus playing a major role in maintaining the erection for a longer time
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shagandha-preclinical
Conclusion

Thus, the study proved that the formulation is very safe and exhibited an excellent aphrodisiac potential use for the management of male sexual dysfunction.